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INS-1 832/3 and MIN6B1 cells were stimulated in serum-free media plus 3 mM glucose and IBMX as indicated, with results expressed relative to time-point-specific IBMX-only baseline

Certain bacteria, including Akkermansia muciniphila, support GLP-1 secretion by improving gut barrier function, reducing inflammation, and promoting the production of short-chain fatty acids

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[1] Any of these ingredients could potentially trigger a reaction in susceptible individuals