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It should not be taken by individuals with a history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2

Additionally, other medications commonly used in patients with metabolic disorders may contribute to sexual dysfunction, including certain antihypertensives (especially thiazide diuretics and beta-blockers), antidepressants (particularly SSRIs), 5-alpha-reductase inhibitors, and opioid analgesics

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Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy