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Each dose increase may temporarily reintroduce mild symptoms as the body adapts to the higher level of GLP-1 receptor activation, but these symptoms generally resolve more quickly than initial side effects

For patients with uncertain family history or unexplained hepatic or neurological symptoms that could be consistent with Wilsons disease, evaluation should precede GHK-Cu therapy

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This extreme potency distinguishes GHK-Cu from many other bioactive peptides and contributes to its therapeutic potential