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SAM allosterically activates mammalian CBS 2.5-5 fold (Janosik et al., 12 deficiency, methionine block implies that SAM (driven by Met) is lowered as well and hence it is plausible CBS is less effective
Five of these 16 patients had the AR mutation T877A
More experienced researchers may prefer higher concentrations for smaller injection volumes, but beginners benefit from the forgiving measurement margins of the 2mL ratio
Safety cannot be established outside of controlled laboratory research
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