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A groundbreaking study has unveiled that lactylation of the Lys131 residue at the N-terminus of cGAS by AARS2 in the wake of viral infection leads to a loss of DNA recognition capacity

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Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)