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None of that changes whats happening in the dermal layer where collagen is produced, where cells divide, and where the structural decisions that determine skin firmness, texture, and healing speed are made
In the chronic injury microenvironment, DAMPs such as fibrinogen induce the expression of arginase 1 (Arg1) and IL-10 through the integrin signaling pathway, promoting the conversion of macrophages toward the M2 phenotype to support tissue repair (Wynn et al., 2013) (193)
When honestly, it seems like that's where some of the greatest benefits come, with regulating hormones
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