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Acknowledgements This work is supported in part by NIH grants AA022057 (VV), AA021724 (VV)
After consumption, it bypasses liver metabolism and travels to your kidneys where it converts into L-arginine, effectively sidestepping the first-pass effect
The kidneys and nervous system are similarly sensitive to biochemical imbalances over time
Additionally, tirzepatide influences neural circuits that regulate hunger signals, reducing the desire to eat and decreasing overall caloric intake
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