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doi: 10.1038/nm.2219 54 DuricV.BanasrM.StockmeierC
Two properties of the native peptide make it impractical as a durable pharmacological agent
Therefore, approval is often easier when the treatment plan looks structured, documented, and clinically responsible
While GLP-1s do reduce appetite and slow gastric emptying, they cant overcome a diet thats significantly higher in calories than your body needs, chronic sleep deprivation, or high stress levels that drive cortisol production and fat storage
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