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The initial stages of individual aging are also closely linked to vascular endothelial senescence (Brandes Ralf et al., 2005)
The rationale for injectable administration stems from the limitations of topical delivery
Although some studies have demonstrated benefits such as increased lean body mass and improved body composition (in populations with clinical need for the drugs), these gains have not consistently translated into enhancements in muscle strength, physical performance, or overall quality of life
Accordingly, all mentioned examples imply the use of as prepared hydrophilic NCs with no surface modifications prior to their encapsulation
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