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Endogenously present in human plasma, its levels decline with age

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The latter has no appreciable biological activity, but is converted by the dipeptidyl carboxypeptidase, Ang-converting enzyme (ACE), to the octapeptide Ang II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) 1, 2, 3 (Figure 1)

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