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The most common ones are usually mild and improve over time: Nausea (especially when starting) Diarrhea or constipation Decreased appetite Fatigue during adjustment period Stomach discomfort Serious But Rare Side Effects More serious side effects are uncommon but require medical attention: Severe allergic reactions Pancreatitis (inflammation of the pancreas) Gallbladder problems Low blood sugar (if combined with diabetes medications) Kidney problems Sleep-Related Considerations Some people report temporary sleep changes when starting GLP-1 medications: Initial insomnia or restlessness (usually improves) Changes in dream patterns Temporary fatigue as body adjusts Mood changes that can affect sleep Most sleep-related side effects resolve within a few weeks as your body adapts to the medication
Koh YG, Jo SB, Kwon OR et al
Keeping a symptom diary during the initial months of semaglutide treatment helps identify patterns and triggers specific to your situation
Using Soliqua 100/33 with TZDs can raise your risk of swelling, which may lead to new or worsening heart failure
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