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For a 2-h half-life peptide, R increases from 1.0 to approximately 1.02a negligible improvement
Injectable peptides bypass the digestive system, which can actually reduce certain types of immune reactions
The most common adverse effects reported during clinical trials with exenatide are gastrointestinal symptoms including vomiting, nausea, and diarrhea, as well as mild to moderate hypoglycemia [44,49-51]
You only need to deal with injection supplies, site rotation, and the hassle of administration once weekly
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