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[6] [2] A 2013 scientific review found there was no conclusive evidence it causes melanoma, [6] and a 2021 review concluded "the increased risk of melanoma in Melanotan users, who use it for tanning and exhibit sun-seeking behaviour, can probably be explained by more UV exposure"

Hereditary cancer syndromes like BRCA1/2 mutations, Lynch syndrome, and Li-Fraumeni syndrome create elevated lifetime cancer risk that persists regardless of current cancer status

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Oxidative stress occurs from normal cellular processes but increasingly from pollution, toxins, stress, and other exposures of modern life