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Preclinical and mechanistic studies were included selectively when they provided mechanistic insights (e.g., muscle metabolism, neural or hormonal pathways)
Selenium status becomes rate-limiting: targeting plasma selenium of 120150 g/L through selenomethionine 200 g/day is more effective in these carriers than in wild-type individuals
Ensure adequate protein intake (typically 0.8-1.2g per kilogram of ideal body weight daily, though requirements vary individually) to preserve muscle mass during weight loss and support energy levels
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