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The agonistic activity of these hybrids were obtained by functional assays using cells expressing the GLP-1R and by measuring the receptor-mediated cAMP produced

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This protective effect was primarily driven by a 30% reduction in liver decompensation events, comprising ascites, hepatic encephalopathy, variceal bleeding, and hepatorenal syndrome (IRR: 0.70, 95%CI: 0.52-0.94, P = 0.020), based on six studies comprising 877,488 participants

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