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Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis
doi: 10.1016/S0140-6736(19)31149-3 25
Based on available research, researchers and regulators believe the risk is rare
But neurons are not the only type of cells in the brain
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