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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Though the multi-drug cocktail therapy has made great progress in gene therapy, due to the different pharmacokinetics and pharmacological characteristics of different drugs, as well as the personalized distribution after systemic administration, the strategy always exhibits potential toxicity and unsatisfactory efficacy in both preclinical and clinical application
Clinical trials on humans are limited
Reference: Cox, H., Miller, G., & Eichner, D
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