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11.2 What GLP-1 Therapy Does Change GLP-1 receptor agonists consistently: Reduce caloric intake Narrow food volume Alter dietary patterns Increase early satiety Promote rapid weight loss in responders These behavioural and physiological changes shift nutritional exposure
Insulin-like growth factor-I response to a single bolus of growth hormone is increased in obesity
In the Phase 2 trial, participants who started directly at 4 mg (without the 2 mg titration period) experienced nearly double the rate of gastrointestinal adverse events compared to those who started at 2 mg (Jastreboff et al., NEJM 2023)
(3) Administration and Metabolism: Mirabegron is administered orally once daily (2550 mg) and undergoes hepatic metabolism via multiple pathways, including dealkylation and oxidation
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