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On the one hand, excess iron ions can directly catalyze ROS production, exacerbating oxidative stress, while also promoting the generation and aggregation of A and catalyzing the hyperphosphorylation of the tau protein
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As such, the AMYR agonists (combined with other incretin class members) could represent the elusive drug candidate to address the multi-hormonal dysregulations of diabetes subtypes and qualify as a precision medicine approach that surpasses the long overdue division into T1DM and T2DM
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