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You are willing to accept (a) investigational status, (b) a 1218% discontinuation rate at the highest doses, and (c) the new dysesthesia signal at ~20% incidence

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The continuous downregulation of naringin, dihydromyricetin, cyanidin, and malvidin 3- O -glucoside might be responsible for the color change in red leaves of Populus euramericana Zhonghuahongye from the R1 to R3 stages