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Replace the pyridine methyl with deuterium, slowing metabolic clearance and alleviating bitter taste, dizziness, and residual sedation
These changes may lead to sensations of dizziness or episodes of fainting if not adequately observed
The mean HbA1c reductions from baseline were 2.01% with 5 mg, 2.24% with 10 mg, and 2.30% with 15 mg of tirzepatide, compared with 1.86% for semaglutide
The peptide did not produce adverse metabolic effects associated with full-length growth hormone, including insulin resistance, glucose intolerance, or IGF-1 elevation
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