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Although one-carbon metabolism occurs in both the cytoplasm and mitochondria, metabolic enzymes, including SHMT in mitochondria but not the cytosol, are upregulated and significantly associated with tumor aggressiveness and prognosis (Jain et al., 2012
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Telomerase is the ribonucleoprotein enzyme responsible for adding TTAGGG repeats to chromosome ends (telomeres), counteracting the progressive shortening that occurs with each cell division
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