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In clinical trials where a GLP-1 RA was added to background basal insulin, a general 20% basal insulin reduction in all patients or a 20% reduction in patients with an A1C 8.0%, the GLP-1 RA can be reasonably initiated without a reduction in the basal insulin dose for many patients
Hypersensitivity: In rare cases (less than 1%), patients may develop a true allergic reaction, characterized by hives, rash, or difficulty breathing
That is a meaningful positive signal
Protein kinase C restricts transport of carnitine by amino acid transporter ATB0,+ apically localized in the bloodbrain barrier
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