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Fatty acid activation is catalyzed by fatty acyl-CoA synthetases (also called acyl-CoA ligases or thiokinases)

More importantly, my co-author, Anna Thalacker-Mercer from the University of Alabama at Birmingham, wondered if B12 supplementation in aged mice would improve muscle mitochondrial function and it did. Previous research has largely concentrated on the visible consequences of B12 deficiency, such as megaloblastic anemia, neuropathy, and cognitive decline, rather than examining the underlying biological mechanisms

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