Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
But chronic stress, poor diet, infections, medications, and inflammatory conditions can damage the intestinal lining, leading to issues like leaky gut, IBS, inflammatory bowel disease (IBD), and food sensitivities
If you are experiencing any of the GI-related symptoms (listed above) make sure to get your GI tract evaluated and treated if necessary
This pharmacokinetic profile enables weekly dosing while maintaining stable therapeutic levels throughout the dosing interval