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3.4 Glucoselipid metabolism and IR Insulin resistance serves as the crucial hub connecting metabolic derangements and reproductive dysfunction in PCOS, making it a primary target for GLP-1RA intervention within the metabolicreproductive axis
The LEADER-6 study shown substantial cardiovascular advantages of liraglutide in high-risk patients, while SUSTAIN-6 revealed a significant decrease in cardiovascular event-related mortality with subcutaneous semaglutide (Verma et al
2020;69:356-OR
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