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The resulting FcFcR complex forms a homodimeric Fc with one ligand, with the FcR offering both N- and C-termini for independent functionalization, enabling single- or dual-payload formats, including masked designs for conditional activation

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A real-world cohort study reported 5.9% weight loss at 3 months (Ghusn 2022), suggesting meaningful changes are typically underway within the first six weeks