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Two-year sustained weight loss and metabolic benefits with controlled release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study

However, maximal glucose-lowering effects generally occur after 45 weeks at a stable dose, once steady-state drug levels are achieved

Lillys oral GLP-1, orforglipron, delivers weight loss of up to an average of 27.3 lbs in first of two pivotal Phase 3 trials in adults with obesity

Thus, exploring the genetic origins of psychiatric disorders or identifying potential therapeutic targets through the lens of genetic variants holds significant practical implications