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The main mechanism of cardioprotective effects of GLP-1R agonists against oxidative stress-induced injury in H9c2 cells (cardiomyoblasts from Rattus norvegicus) and in cardiomyocytes is related to the scavenging of reactive oxygen species, by increasing the concentrations of endogenous antioxidant defenses and inhibiting cardiomyocyte apoptosis [42]
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Diabetic neuropathy benefits Perhaps most relevant to the semaglutide discussion, research demonstrates that GLP-1 receptor agonists can ameliorate diabetic neuropathic pain by inhibiting neuroinflammation in the spinal cord
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