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For example, semaglutide can help you lose 15% of your weight in 68 weeks, while an older drug, Contrave, has been shown to result in closer to a 5% weight loss
Summary: Retatrutide commonly causes bowel changes including diarrhoea, constipation, and abdominal discomfort due to its activation of GLP-1 receptors throughout the gastrointestinal tract, which alters gut motility
This effect is due to the fact that GLP-1RAs suppress appetite and reduce energy intake at a central nervous system level
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