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Comprehensive evaluation should include complete thyroid panel (not just TSH), fasting insulin and HOMA-IR for insulin resistance assessment, cortisol testing for adrenal dysfunction, sex hormone panel (testosterone, estrogen, progesterone), sleep study if sleep apnea is suspected, medication review for weight-promoting drugs, and psychological evaluation for eating disorders or food addiction

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Given the complex interplay between metabolism, bone development, cell differentiation, and the gut microbiota during growth, these pharmacological interventions must be applied with caution and supported by robust longitudinal evidence

It is explored for its role in supporting cellular recovery, angiogenesis, and protective biological pathways