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When a supplement might make sense A supplement conversation can be reasonable if someone has factors like: Very low protein intake or restrictive dieting Significant gut issues affecting digestion and absorption Higher oxidative stress burden, higher toxicant exposure, or intense lifestyle strain A medical context where a clinician is monitoring symptoms and labs If none of that applies, the best first step is almost always food and fundamentals

Arthur JR, McKenzie RC, Beckett GJ

For example, its effects on poultry are primarily mediated through microbial fermentation in the large intestine, where soluble fibers are broken down into short-chain fatty acids (SCFAs) such as butyrate, acetate, and propionate

Even yet, more study is required before FMT may be used to treat depression