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Current Phase 3 trials (expected to report results in 2027) are exploring doses ranging from 4mg to 12mg weekly, with some protocols testing up to 16mg

When combined with semaglutide (CagriSema), weight loss increases to 15-25%, making it one of the most powerful medical weight loss options available

These findings suggest that endothelial IGF- 1R signaling is essential for maintaining skeletal muscle capillary density, and its deficiency leads to impaired vascular supply, potentially contributing to exercise intolerance and muscle fatigue in KD mice

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