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Supercritical fluid extraction, particularly with supercritical carbon dioxide (CO 2 ), offers several advantages for the extraction of polyphenols (59)
They must either have: BMI of at least 35 BMI of at least 30 plus a history of heart failure, uncontrolled hypertension or chronic kidney disease BMI of at least 27 plus prediabetes, a previous heart attack or stroke, or symptomatic peripheral artery disease
Its also common to experience a temporary return of symptoms after a dose increase
