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The peptide upregulates growth hormone receptors on tendon fibroblasts, enhances neurotrophic factor expression, and promotes angiogenesis through the VEGFR2-Akt-eNOS signaling pathway

Best Peptides to Stack with IGF-1 LR3 GH secretagogues like CJC-1295 and Ipamorelin increase plasma GH and IGF-1 levels, mimicking natural hormone pulses while reducing side effects. Merriam et al., Endocrinology and Metabolism Clinics Sample Peptide Stack Protocol with IGF-1 LR3 Goal: Muscle growth, fat loss, and joint recovery IGF-1 LR3 4080 mcg per day (post-workout or split AM/PM) CJC-1295 w/ DAC 2 mg once weekly Ipamorelin 100 mcg 23x daily (AM, pre-bed, post-training) TB-500 25 mg weekly (split dose) BPC-157 250500 mcg 12x daily for site-specific healing Note: Peptide timing should support circadian rhythm, with GH secretagogues ideally used pre-bed or post-training for maximum recovery

doi:10.2305/IUCN.UK.2022-1.RLTS.T58578A193376512.en

PMID 20599753