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The two aren't interchangeable, and the expected magnitude of effect isn't comparable - supplements are not positioned by credible sources as equivalent alternatives to prescription GLP-1 medication

In 2018, the Amgen team updated a new invention patent titled "Methods for Treating or Ameliorating Metabolic Disorders Using a Gastric Inhibitory Polypeptide Receptor Antagonist Bound to a Glucagon-Like Peptide-1 Receptor Agonist Fusion Protein (WO2018237095A1)." In this patent, researchers have created a fusion by linking the carboxyl-terminal end of a GLP-1 analog to the amino-terminal end of either the light chain variable region or the heavy chain variable region of an antibody or its functional fragment capable of binding to the GIPR receptor