If any unusual symptoms appear whilst using them then consult a doctor straight away to ensure that you are safe and healthy
In patients with type 2 diabetes, treatment with semaglutide resulted in the following relative reductions in glucagon compared to placebo, fasting glucagon (8%), postprandial glucagon response (14 to 15%), and mean 24-hour glucagon concentration (12%)
Zieminska E, Toczylowska B, Diamandakis D, Hilgier W, Filipkowski RK, Polowy R, Orzel J, Gorka M, Lazarewicz JW
The most commonly reported injection site symptoms include: Erythema and warmth transient redness and increased temperature at the injection location Pruritus localized itching that generally resolves within hours to days Induration firm swelling or hardness of subcutaneous tissue Bruising ecchymosis from capillary disruption during injection Pain or tenderness mild discomfort that typically diminishes rapidly While generalized skin sensitivity is not among the most common adverse effects, the FDA labels for both Mounjaro and Zepbound include warnings about the potential for serious hypersensitivity reactions, including anaphylaxis and angioedema, though these are rare