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L-citrulline converts to arginine in the kidneys and escapes the arginase and first-pass metabolism that removes much of an oral arginine dose.[10]L-Citrulline vs L-Arginine Pharmacokinetics Br J Clin Pharmacol (2008) View source That makes citrulline more efficient per gram for plasma arginine, while arginine keeps the deeper blood pressure dataset
Circulation 137 , 975977 (2018)
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Liraglutide improves vascular dysfunction by regulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue in obese mice
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