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Pregnant or breastfeeding individuals are generally not prescribed these medications due to safety concerns (FDA Wegovy safety warnings)
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits (review)
They also have a boxed warning regarding thyroid C-cell tumors observed in rodents (though human relevance remains uncertain)
The delayed gastric emptying characteristic of these medications means that food remains in the stomach longer, which can cause discomfort during exercise if meals are poorly timed
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