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Lastly, among rats, the administration of wortmannin (a fungal metabolite) which induces hyperphosphorylation of tau in hippocampal pyramidal neurons, can be partly attenuated by preinjection of melatonin [117, 118], underscoring melatonins potential therapeutic role
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Consistent with these data, we found that rotenone inhibited mTOR-mediated p70S6K and 4E-BP1 activity and triggered neuronal apoptosis, as detected by increased expression of cleaved-caspase-3 in vivo (Fig
Bindoli A, Fukuto JM, Forman HJ
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