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LNPs can typically be designed with a specific surface charge to either increase or reduce electrostatic interactions with mucins, such as through the incorporation of chitosan or cationic amphiphilic drugs 124,191
When GI adverse effects remain severe or refractory despite these measures, temporary discontinuation of GLP-1 RA therapy or a structured drug holiday may be appropriate
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All of the local, state, and federal regulations should be adhered to by the researchers who will work with and use this product
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