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The conserved lysine residue N-terminal to the active site, Cys A , helix 1 and helix 3 as well as the -sheets of the thioredoxin fold are almost perfectly superimposed
Cold storage simply slows the chemical reactions that degrade a peptide, whereas freezing forms ice crystals that can unfold and clump the peptide chains, and that damage does not reverse on thawing
individuals with Wilson's disease or those who are pregnant should seek medical advice before use
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