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In vivo biological tests utilized C57BL/6 mice subjected to a subacute PD model induced by daily intravenous administration of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (40 mg/kg) for seven days

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The researchers found that P493 cells rely on a glutamine-driven TCA cycle independent of glucose and that inhibiting GLS curbs tumour cell proliferation both in vitro and in vivo

Gain-of-function mutation in ACOX1, Mitchell Syndrome: Gain-of-function mutation in peroxisomal acyl-CoA oxidase 1 (ACOX1) is a very rare heterozygous missense variant (p