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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: February 28, 2026 GHK-Cu is a copper peptide complex (glycyl-histidyl-lysine combined with copper) that naturally occurs in human saliva, plasma, and urine

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In vivo studies reveled that apigenin treatment reduced tumor growth and a significant decrease in HDAC activity that correlated with increased levels of p21/waf1and Bax protein along with a reduction in protein levels of bcl2 that favored apoptosis in tumor cells of the mice (Pandey et al., 2012)