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If we can actually get this drug into our patients, we are going to see an even more profound reduction in the epidemiology of CKD that was kick-started by RAS inhibitors 2 decades ago and amplified by flozination in the last few years.

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Convenience = Big Win Orforglipron: No strict fasting requirement Semaglutide: Requires empty stomach + timing discipline In a real-world Indian setting, this alone can drive switching --- 3