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The amplitude (A) of spontaneous and Ca 2+ -induced swelling of the organelle suspension in a Ca 2+ -free medium and in the conditions of pore-formation activation with the action of PTP inducer of swelling of calcium ions was calculated as the difference in optical density values from 1 to 15 min mPTP-associated mitochondrial swelling was tested by the specific mPTP inhibitor cyclosporin A (CsA), which was added to the incubation medium in a concentration of 10 5 mol/L 5 min before the induction of pore formation

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Alla fine del periodo di studio di 56 settimane, nei bracci dei pazienti trattati con liraglutide si registrato non solo un calo ponderale significativo, ma anche la riduzione del rapporto albumina/creatinina urinarie (UACR) nella misura del 18,36, 10,79 e del 2,34%, rispettivamente

Since the 2000s, incretin-based therapies for diabetes and obesity have become the focus of research and clinical practice