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Lancet 397 , 23722384 (2021)

NAD+ Injection (Compounded) NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in the body, essential for energy metabolism, DNA repair, and cellular signaling

Whether tirzepatide would benefit kidney function in people with preexisting CKD requires a dedicated study

Sitting with someone in their ambivalence and the discrepancy between their values and actions (and the shame which can sometimes surround that), understanding their perspective, and helping them work through competing motivations is far harder to replicate (yes, at least)