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Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30
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About four in ten adults ages 50 to 64 and 65 and older say they have heard a lot about GLP-1 drugs, compared to about one-third of adults ages 30-49 (32%) and one in six adults ages 18-29 (17%)
Laboratory and animal studies suggest GLP-1 receptor agonists may also inhibit nuclear factor-kappa B (NF-B) signaling, a key pathway in inflammatory gene expression, and reduce oxidative stress through enhanced antioxidant enzyme activity
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