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In addition to treating the cardiac stresses that occur with obesity and associated morbidities, such as OSA, additional cardiovascular benefits of GLP-1s are thought to be mediated by their action on vascular smooth muscle cells and endothelial cells
Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, Bleichert S, Saleh L, Knfler M, Zeisler H, Hengstschlger M, Rosner M, Salzer H, Gundacker C (2015) Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters
Safety and Side Effects Tirzepatide is effective but not risk-free
Vedolizumabs mechanism involves selective inhibition of 47-MAdCAM-1 binding to prevent gut-homing of lymphocytes while preserving systemic immunity as demonstrated by maintained humoral responses to parenteral vaccines but blocked responses to oral vaccines, with proposed effects on nave T and B cell trafficking to intestinal inductive sites and attenuation of lymphoid aggregates contributing to therapeutic benefit beyond simple effector cell blockade
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