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Activation of MC1R in melanocytes stimulates the production and distribution of melanin, leading to increased skin pigmentation even without ultraviolet (UV) exposure
Tomassini, V., Pozzilli, C., Onesti, E., Pasqualetti, P., Marinelli, F., Pisani, A., and Fieschi, C
However, the higher baseline HbA1c in the PIONEER 3 trial (8.31% in PIONEER 3 compared with 7.96% in PIONEER 4) was felt to be more aligned with target population in Portugal, and to correlate with the large reductions in HbA1c observed in the NMA with oral semaglutide 14 mg, and therefore the PIONEER 3 data were used in the base case analysis
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